Devices for Inner Ear Stimulation and Monitoring

We are developing novel devices for electrical stimulation and sensing of the inner ear.  In collaboration with Dr. Anantha Chandrakasan (Electrical Engineering, MIT), we demonstrated that energy can be extracted from the biological battery in the inner ear to run electronics, without damaging hearing (Mercier et al, 2012). This opens future possibilities for autonomous sensing of the inner ear and its environment. We also developed a low-power prototype signal-processing chip for a fully implantable cochlear implant that can be wirelessly recharged using an ordinary cell phone (Yip et al, 2014). To enable clinical translation of this technology, we defined and tested (in patients with cochlear implants) an energy-efficient waveform for electrical stimulation of the cochlear nerve (Yip et al, 2017). A fully implantable cochlear implant has a potential to overcome the social stigma and functional limitations associated with the current commercial devices that have a visible, external component.

Publications

Orguc S, Khurana HS, Stankovic KM, Lee HS, Chandrakasan AP. EMG-Based Real Time Facial Gesture Recognition for Stress Monitoring. IEEE International Engineering in Medicine and Biology Conference Proceedings 2018. Accepted.

Yip M, Bowers P, Noel V, Chandrakasan A, Stankovic KM. Energy-Efficient Waveform for Electrical Stimulation of the Cochlear NerveScientific Reports 2017;7(1):13582.

Sahin MI, Sagers JEStankovic KM. Cochlear Implantation: Vast Unmet Need to Address Deafness Globally. Otology and Neurotology. 2017 May 2. 

Yip M, Jin R, Nakajima H, Stankovic KM, Chandrakasan AP. A Fully Implantable Cochlear Implant SoC with Piezoelectric Middle Ear Sensor and Arbitrary Waveform Neural Stimulator. IEEE J of Solid-State Circuits 2014; 50(1):214-229.

Yip M, Jin R, Nakajima H, Stankovic KM, Chandrakasan AP. A Fully Implantable Cochlear Implant SoC with Piezoelectric Middle Ear Sensor and Energy-Efficient Stimulation in 0.18 um HVCMOC. International Solid-State Circuits Conference proceeding 2014;312-313.

  • This paper describing the prototype chip for a fully implantable cochlear implant has received international media attention. Dr. Stankovic was interviewed by National Public Radio, New England Cable News, Al Hurra TV (The Middle East Broadcasting Networks), IEEE Spectrum, Reuters Health. In addition, our findings were reported by CBS news, ABC news, The Times of India.
  • This paper was voted as one of the top 5 papers at the conference by EETimes.

Bandyopadhyay S, Mercier PP, Lysaght AC, Stankovic KM, Chandrakasan AP. A 1.1nW Energy Harvesting System with 544pW Quiescent Power for Next Generation Implants. IEEE J of Solid-State Circuits 2014; 49(12):2812-2824.

Bandyopadhyay S, Mercier PP, Lysaght AC, Stankovic KM, Chandrakasan AP. A 1.1nW Energy Harvesting System with 544pW Quiescent Power for Next Generation Implants. International Solid-State Circuits Conference proceeding 2014;396-397.

Mercier P, Bandyopadhyay S, Lysaght A, Stankovic KM, Chandrakasan AP. A sub-nW 2.4 GHz Transmitter for Low Data-Rate Sensing Applications. IEEE J of Solid-State Circuits 2014; 49(7):1463-1474.

Mercier P, Bandyopadhyay S, Lysaght A, Stankovic KM, Chandrakasan AP. A 78 pW 1 b/s 2.4 GHz Radio Transmitter for Near-Zero-Power Sensing Applications. European Solid State Circuits (ESSCIRC) Conference proceedings 2013;133-136.

Mercier P*, Lysaght A*, Bandyopadhyay S*, Chandrakasan AP&, Stankovic KM&Energy Extraction from the Biologic Battery in the Inner Ear. Nature Biotechnology. 2012; 30(12): 1240-3 (*/& = equal contribution). Featured on cover page; received worldwide press coverage.

Dr. Stankovic was interviewed by the Wall Street Journal, Canadian Broadcasting Corporation, the Danish Broadcasting Corporation, Medtronic EUreka, Instituto Ciencia Hoje (Brazil), Horakustik (Germany), and IEEE Spectrum in regard to this research. In addition, our findings were reported by the Los Angeles Times, Discover Magazine, The Scientist, Massachusetts Society for Medical Research, Science News for Kids, Discovery News, Hearing Journal, Tech News Daily, and New Scientist.