Lab News

June 2017

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Lukas Landegger's newest paper, "Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research," is featured on the JoVE homepage. Congratulations, Lukas!

Jessica Sagers wins the Amelia Peabody Scholarship to support her PhD studies. Congratulations, Jessica!

 

April 2017

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Yin Ren wins the first place poster award at the Spring Meeting of the American Otological Society in San Diego, CA for his work on tumor-penetrating nanocomplexes for delivery of siRNA therapeutics to human vestibular schwannomas. Congratulations, Yin!

TinaJanani Iyer and collaborators at École Polytechnique Federale de Lausanne in Switzerland are featured in YouTube videos describing new methods of imaging the inner ear. This research is sponsored by the Bertarelli Foundation:

https://www.youtube.com/watch?v=zZnCogLGzOo&feature=youtu.be

https://www.youtube.com/watch?v=_N4lr17rQ4I

Janani Iyer wins a National Defense Science and Engineering Graduate (NDSEG) Fellowship. The NDSEG Fellowship is sponsored and funded by the Department of Defense. Congratulations, Jan!

February 2017

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Lab dinner to celebrate Maura Eggink's time with our lab! Maura will be returning to the Netherlands to finish her medical degree. We'll miss you, Maura!

 
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Lukas Landegger's paper on a synthetic AAV vector that enables safe and efficient gene transfer to the mammalian inner ear was published online by Nature Biotechnology. The paper was featured on the MEE web site, Harvard Medical School News, Nature Reviews Drug Discovery, and Nature Research Highlights, as well as by numerous media outlets worldwide, including Japan TimesEl PaísRTMirrorYahoo NewsCTVNews.com.au, Medical University of Vienna (English here), Bild der Wissenschaft, Economic Times, and ORF. Congratulations, Lukas!

 

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Vitor Soares defends his PhD dissertation at the University of Brasilia, Brazil. His thesis is entitled "The Role of Extracellular Vesicles in the Pathophysiology of Hearing Loss Caused by Vestibular Schwannoma." Congratulations, Vitor!

December 2016

Brian Lin's most recent paper, "Duration of Analgesic Use and Risk of Hearing Loss in Women" (Am J Epidemiol, 2016), was featured in the New York Times. The entire article is available here. Congratulations, Brian!

November 2016

Lab dinner at Gourmet Dumpling House in Chinatown!

September 2016

Lab sailing outing in beautiful Marblehead, MA!

Lukas Landegger wins Hansaton Science Prize from Austria for research. He presented a poster on secreted factors from vestibular schwannoma that can cause direct cochlear damage. Congratulations, Lukas!

Tina and Jessica Sagers participate in the "Listening into 2030" meeting in Berkeley, California. The meeting focused on imagineering the future of communication science. Attendees included many Eaton Peabody Laboratory (EPL) and MIT/Harvard alumni and current students (pictured). Tina was an invited speaker and Jessica won a National Science Foundation Travel Award to participate. Congratulations, Jessica!

August 2016

Tina presents at the annual meeting of the Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum in Bordeaux, France. Tina presented the lab's latest research on mechanisms of vestibular schwannoma-induced hearing loss.

Tina gives a keynote talk at the 4th Yonsei Acoustic Tumor Conference in Seoul, South Korea. Her talk entitled “Vestibular schwannoma: from bedside to bench and back” summarized the lab’s research on developing pharmacotherapies for vestibular schwannoma and the associated hearing loss.

A day before, Tina gave an invited talk at Asan Medical Center in Seoul, South Korea. Her talk entitled “Research vistas in otology: from bench to trench” highlighted the lab’s focus on developing better diagnostics and therapeutics for sensorineural hearing loss. Afterwards, friends and colleagues (including former lab members) gathered for dinner.

Janani Iyer's paper on the first application of micro optical coherence tomography to image intracochlear structures has been accepted for publication by Scientific Reports. Congratulations, Jan!

June 2016

Lab dinner in Back Bay for Hsiao-Chun Lin's farewell! We will miss you! Congrats on your strong work and best of luck on your PhD studies at the University of Tokyo, Japan!

Tina is Visiting Professor and Distinguished Guest Judge at the annual Resident and Fellow Research Presentation Day, Department of Otolaryngology, University of Miami Miller School of Medicine.

Yin Ren wins a CORE grant from the American Academy of Otolaryngology – Head and Neck Surgery entitled “Tumor-penetrating delivery of nanoparticles to human vestibular schwannomas.” Congratulations, Yin!

International fellows and colleagues gather at the triennial International Otopathology Society meeting in Boston. Lukas presented a talk entitled “Human audiometric thresholds do not predict specific cellular damage in the inner ear,” and Tina presented a talk entitled “Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.” Former fellow Chen-Chi Wu presented a talk entitled “Genetic determinants of poor cochlear implantation outcomes and the associated molecular pathology."

May 2016


Our collaborators from Ecole Polytechnique Federale de Lausanne in Switzerland spent 2 weeks with us in Boston, testing a prototype endoscope for intracochlear imaging. Jan will be joining them in Switzerland for 6 weeks, as a Bertarelli fellow.


Tina gives talks on the latest research from the lab as the invited US otologist at the VII International Otology and Neurotology Meeting in Medellin, Colombia.

April 2016

Yin Ren wins NEOS (New England Otolaryngological Society) Resident Research Grant Award. Congratulations, Yin!

March 2016

Jessie West presents at Eastern Sociological Society Meeting. Jessica gave a talk entitled “Exploring strategies for telling others about hearing loss” in a panel called “To Stink or Not to Stink: Working with Labeled, Stigmatized and Discredited Bodies” at the meeting in Boston, MA. Congratulations, Jessie! She will be presenting a related poster at HEAL 2016 meeting in June at Lake Como, Italy and at the American Sociological Association’s annual meeting in Seattle in August.

Lukas Landegger receives Meritorious Abstract Travel Award from the American Society of Gene and Cell Therapy (ASGCT).  Lukas will be presenting a talk entitled “Efficient transduction of neurosensory hair cells in the cochlea with synthetic AAV vectors” at the annual meeting in Washington, DC. Congratulations, Lukas!

February 2016

Takeshi and Kyoko’s Farewell Party. Takeshi and Kyoko Fujita were post-doctoral research fellows with us for two years. They have done a wonderful job and we’ll miss them. We wish them all the best back home in Japan!

Lukas Landegger presents at ARO. Lukas presented a talk entitled “Secreted factors from human vestibular schwannomas can cause cochlear damage” at the ARO meeting in San Diego. Congratulations, Lukas! The paper was published a few months earlier in Scientific Reports.

Shyan-Yuan Kao presents at ARO. Shyan-Yuan presented a poster entitled “Activation of TRAIL-DRG pathway promotes sensorineural degeneration in the inner ear” at the ARO meeting in San Diego.  A detailed paper was recently published in Aging Cell. Congratulations, Shyan-Yuan!

January 2016

Janani Iyer joins SHBT PhD program. After working in the lab for 6 months as a research assistant, Jan joins the SHBT program as a PhD student. Congratulations, Jan!

HIGHLIGHTS FROM PRIOR YEARS

2015

Our 2015 lab photo!

Tina presents honorary Howard House, MD Lecture for Advances in Otology at the Academy meetingTina gives a lecture entitled “Modern otology: A nexus of surgery, neuroscience and biotechnology” at the annual meeting of the American Academy of Otolaryngology – Head and Neck Surgery in Dallas, Texas.

Tina wins Benjamins Prize from the Collegium Oto-Rhino-Laryngologicum Amictiae Sacrum. Tina presented a talk entitled “Transactivation of human osteoprotegerin promoter by GATA3: implications for treatment of sensorineural hearing loss” at the meeting in San Diego, California.

Taha Jan receives CORE grant from the American Academy of Otolaryngology – Head and Neck Surgery. Taha’s grant is entitled “Effects of secreted factors from human vestibular schwannomas on hearing." Congratulations, Taha!

Vitor Soares gets married in Brazil. Sonam Dilwali and Jessie West went to his wedding. Congratulations, Vitor!

Tina is Neurofibromatosis Research Program (NFRP) featured New Investigator, Department of Defense. Three of the laboratory’s research papers were highlighted.

Lukas Landegger wins the prestigious Heinz Kurz poster prize at the Austrian otolaryngology conference. Lukas presented a poster entitled “Human audiometric thresholds do not predict specific cellular damage in the inner ear” in Vienna, Austria and at the ARO meeting in Baltimore, Maryland. The subsequent paper was recently published in Hearing Research.

We held a farewell party for Shelley Batts, one of our postdoctoral fellows. Good luck in your future endeavors, Shelley!

2014

Middle East Update in Otolaryngology, Dubai, United Arab Emirates. Tina presents the latest translational research from the lab as invited faculty.

Marcus Yip’s paper on a prototype chip for a fully implantable cochlear implants receives international media coverage. The conference paper was published in International Solid-State Circuits Conference Proceedings and the journal paper was published in IEEE J of Solid-State Circuits

  • News about this was broadcasted by National Public Radio, New England Cable News, Al Hurra TV (The Middle East Broadcasting Networks), IEEE Spectrum, Reuters Health, CBS news, ABC news, and The Times of India.

Tina receives Thomas A. McMahon Mentoring Award from Harvard-MIT Division of Health Sciences and Technology.

Jane Jensen defends her PhD dissertation at the University of Copenhagen, Denmark. Jane’s dissertation is entitled “Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Adolescent Mice.” Congratulations, Jane!

Andrew Lysaght defends his PhD dissertation at MIT, Harvard-MIT Division of HST, SHBT program. Andrew’s thesis was entitled ”Characterization of Cochlear Transcription, Translation and Energy Extraction in Aging and Noise-Induced Pathology.” Congratulations, Andrew!

Sonam Diwali defends her PhD dissertation at MIT, Harvard-MIT Division of HST, SHBT program. Sonam’s thesis was entitled “From Bench to Bedside: Elucidating Vestibular Schwannoma Pathobiology to Devise Effective Pharmacotherapies.” Congratulations, Sonam!

Tjeerd Muurling wins the prestigious Leiden University Medical Center Student Research Award. Tjeerd’s paper “Metabolomic and network analysis of pharmacotherapies for sensorineural hearing loss” was published in Otology and Neurotology. Congratulations, Tjeerd!

Tina is President of the American Auditory Society.

2013

Festschrift in Honor of Professor Joseph B. Nadol, Jr. Tina gives an invited talk on mechanisms of hearing loss due to vestibular schwannoma.

2013 lab photo!

Tina is President Elect and Program Committee Chair, American Auditory Society.

Tina presents in a symposium on bionic medicine at the American Association for the Advancement of Science meeting.

Sonam Dilwali wins a first place poster award from the American College of Surgeons. Sonam presented poster entitled “Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas” at the annual meeting of the Massachusetts Chapter Society in Boston. The subsequent paper was published in Translational Research.

Sonam also received a second place poster award at the Spring Meeting of the American Neurotology Society in Orlando, Florida.

Camaraderie inside and outside the lab!

2012

In collaboration with Anantha Chandrakasan’s group at MIT, we were first to demonstrate that energy can be extracted from the biological battery in the inner ear. The paper was highlighted on the cover page of Nature Biotechnology and received international media attention.

  • News about this work was broadcasted by the Wall Street Journal, Canadian Broadcasting Corporation, the Danish Broadcasting Corporation, Medtronic EUreka, Instituto Ciencia Hoje (Brazil), Horakustik (Germany), IEEE Spectrum, Los Angeles Times, Discover Magazine, The Scientist, Massachusetts Society for Medical Research, Science News for Kids, Discovery News, Hearing Journal, Tech News Daily, and New Scientist.

2010

Tina wins Harvard Medical School Eleanor and Miles Shore Fellowship, Program for Scholars in Medicine. 

Colleagues gather at the triennial International Otopathology Society meeting in Boston.

Massachusetts Eye and Ear Gala.

Lab picnic!